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BINNARY GASTRIC DLBCL (1033228) »
LMO2 in BOTH.jpg
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Case
presentation
Filename:
LMO2 in BOTH.jpg
[
BINNARY GASTRIC DLBCL
]
54 yrs lady with biopsied "MALToma". Case resent to hemato for reevaluation.
CLINICAL HISTORY: 2013 radical resection of cervical squamous carcinoma with lymphonodectomy.
Gastric PALPABLE pyloric circular tumor with sonoscopically detected spread into anterior abdominal wall with hepatic hilar lymphadenopathy.
PB: isolated anemia. No generalized lymphadenopathy present.
HISTO: bicomponent DLBCL in gastric mucosa: component A more interglandular DIFFUSE, component B more solid and NODULAR.
IH: complettelly divergent:
SUMMARY: (nonGCB/ABC): EBER(-); CD20+; CD30+; Mum1/Bcl6/lmo2/GCET1/FoxP1+; CMYC+; CD5/Bcl2/CD10/CD138/CyclinD1(-); Ki67 prolif. index 70%.
A: Mum1+; CD10(-); CD30+; Bcl6/LMO2(+/-); GCET1(-); FoxP1+;
B: Mum1(-); CD10(-); CD30(-); Bcl6/LMO2+; GCET1+; FoxP1+;
DIAGNOSIS: DLBCL, but probably biclonal?
SPECIAL QUEST: Summarising DLBCL, ABC (by IH). But component A- pure ABC, B- more close to GCB.
ThankYouALot.
Sender:
ugnius
2018-12-03 12:45
INCTR - EBMWG Hematopathology Online
original image:
LMO2 in BOTH.jpg
(69.6 KB)
Last modified:
2018-12-03 12:45:15
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