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Thymic Hyperplasia with LESA features (1194329) » HE3.jpg
Filename: HE3.jpg
[Thymic Hyperplasia with LESA features]
CASE IS OPEN FOR DISCUSSION:  
75 yrs old male with resected mediastinal mass.  
MACRO: Fatty tissue piece of 6x4,5x2 cm. Lobated greyish tumor with defined margins 2,5x2x2 cm with yellowish cyst 1,2x1x0,6 cm. 4 lymph nodes up to 0,5 cm found.  
HISTO: fat tissue with "tumor":  
- Lymphoid stroma with II lymphoid follicles (without TdT+ lymphoblasts) and epithelial proliferation (cysts, strands, serpantines);  
- Cysts with hyalinised walls and papillary epithelial formations;  
- 1 lymphoid nodule within cyst with epithelial diffuse network (block 3).  
- Thymus residual nests with TdT+ cells at periphery and 4 reactive nodes (not included).  
 
PROPOSAL:  
Thymic Hyperplasia With Lymphoepithelial Sialadenitis (LESA)–like Features with multilocular thymic cyst.  
Reactive lymphadenopathy (4).  
 
QUESTION:  
 
Single nodule with diffuse PanCK+ network within cyst avoiding TdT+ lymphobblasts (thymoma B like).  
LITERATURE:  
Weissferdt A, Moran CA. Thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features: a clinicopathologic and immunohistochemical study of 4 cases. Am J Clin Pathol. 2012;138(6):816-822.  
 
ThanYouaLot.
Sender: ugnius
2020-09-26 15:39
INCTR - EBMWG Hematopathology Online

Last modified: 2020-09-26 15:40:13