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Kikuchi's disease, necrotizing lymphadenitis (3350) » CD30 nodule 3.jpg
Filename: CD30 nodule 3.jpg
[Kikuchi's disease, necrotizing lymphadenitis]
32 yrs old male with disseminated lymhadenopathy and suspition of lymphoma. Lateral neck lymph node was taken.  
HISTO: The pale nodules with histyocytic infiltrates, coalescent nodules of acellular necrosis, crescentic histiocytes MPO+/CD68+, predominating CD8+ cells around. Some T salt'n'pepper nodules and reactive follicles are present.  
BUT... Some nodules with HL like giant cells CD30+ CD15-. Some large perinecrotic cells CD15+ CD30-(maybe histiocytic? granuliocytic?).  
IH: Giant cells: CD30+ CD15- ALK1- EBVLMP1-; PALE AREAS (PRENECROTIC/HISTIOCYTIC): CD8 slightly >CD4 (mixture), CD68+/MPO+ histyocytes.  
 
PROPOSAL: Necrotic/Kikuchi lymphadenitis with HL like cells.  
Thank you for your attention.
Sender: ugnius
2007-07-04 10:15
INCTR - EBMWG Hematopathology Online

Last modified: 2007-07-04 10:15:42