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Lymphoplasmacytic lymphoma (3804) »
HE 2.jpg
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Case
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Filename:
HE 2.jpg
[
Lymphoplasmacytic lymphoma
]
63 yrs woman with clinical diagnosis LPL/Waldenstrom from 2002. Recently it was noticed weight loss and IgG raises up.
HISTORY: 2002 anemia and ESR elevation (113). Blood: Leu 11,9; Hb 86g/l;RBC 3,22; PLT 294; PROTEINS: general 95,2g/l(albumins 35,5%; globulins 65.5%; ... gama globulins 42.2% with monoclone); IgM 25.58g/l, IgG 24.87g/l. Urine protein 0.27g/l. BM imprint: 68% small lymphos.
HISTO: B lymphoplasmacytic lymphoma with IgM expression. II° reticulin fibrosis.
IH: CD20(++) 80% (citopl. r-ja), CD23(-), CD3/CD5(-)(except T), Ki67+ 5%, CyclinD1/Bcl6/CD10/Mum1(-), IgM(+/+++) 60%, IgD(-).
CD138(+++)plasmacytes 20%: Ig kappa (+++)/Ig lambda apie 2-3/1, Mum1(++). Mastocytes CD117+.
QUESTION: IgM and IgD expression in both ("CLL and LIKE: part1 and 2") cases with plasmacytoid differentiation.
Thank you for participation.
Sender:
ugnius
2007-09-25 12:08
INCTR - EBMWG Hematopathology Online
original image:
HE 2.jpg
(77.4 KB)
Last modified:
2007-09-25 12:08:35
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