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bone marrow infiltrates by marginal zone lymphoma. A lymph node biopsy is recommended for confirmation (4422) » PAS1.jpg
Filename: PAS1.jpg
[bone marrow infiltrates by marginal zone lymphoma. A lymph node biopsy is recommended for confirmation]
We present here a case of a-40-year old Bosnian male that presented hepatosplenomegalia and generalized lymphadenopathy. He was diagnosed with CLL in 2003 followed by two cycles of chemotherapy.  
Sternal punctate as well as bone marrow biopsy findings are presented here.  
Bone marrow showed a nodal proliferation of the population of small, scattered lymphocytes ("centrocyte-like" cells) along with myelo-monocytic proliferation.  
Immunohistochemistry: CD23(negative, stains only follicular dendritic cells), CD43(+), Bcl-2(+), Bcl-6(-), CD20(+), CD10(-), CD5(-), Cyclin D1(-).  
Additional immunohistohemistry (CD34 & CD14) will follow soon and will be updated here.  
Clinical diagnosis: NHL  
Histopathological diagnosis: Marginal zone B-lymphoma?  
Please, give your opinion.
Sender: semir
2007-12-14 23:03
INCTR - EBMWG Hematopathology Online

Last modified: 2007-12-14 23:03:20