42 yrs old male underwent mesenteric LN biopsy during surgery procedure.
HISTORY: Clin. dgn.: "Acute mesenterial lymphadenitis". 5 days duration of right ileacal pain and urgent surgery with suspition of acute appendicitis.
HISTO: Several I follicles, single II follicles, expanded paracortical T area with pleomorphic "immunoblasts" (HL like) in perifollicullar zone are present with background of small lymphos, some eos and scattered plasma cells. Some signs of hemophagocytosis are present too. Some large cells in T cell background.
IH: Giant cells: CD30+ CD15-CD20/CD3- CD79a+ LCA+/-(?) CyclinD1/p53-(single +?) Bcl6+/- 20% EMA- Mum1+.
WORKING DIAGNOSIS: Immunoblastic lymphadenopathy HL like vs ...
Reactive hyperplasia with B-cell activation and CD30 positivity