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Reactive follicular hyperplasia and early progressive transformation of germinal centers (4574) » CD5x20.jpg
Filename: CD5x20.jpg
[Reactive follicular hyperplasia and early progressive transformation of germinal centers]
We present here of the cervical lymphadenopathy in a-42-year old female. Two suspected lymph nodes were surgically removed of which larger one measured 3.2x1.8 cm while another measured 1x0.4 cm.  
Microscopically, a preserved germ centers with enlarged marginal zones of the follicles were a dominant feature. Lymphocytes in marginal zones were of monocytoid appearance with their progagation into interfollicular areas which contained proliferating blood vessels with some plasma cells and eosinophils.  
Immunohistochemistry: CD20(+), Bcl-2(positive in interfollicular and marginal zone), CD3(sporadically positive in interfollicular areas), IgD(+), IgG(-/+), CD43(-), CD5(-).  
Clinical diagnosis: No  
Histopathological diagnosis: Marginal zone lymphoma?  
Please, give your opinion.
Sender: semir
2008-01-09 23:08
INCTR - EBMWG Hematopathology Online

Last modified: 2008-01-09 23:08:13