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Diffuse large B-Cell Lymphoma (5310) » endometrium 2.jpg
Filename: endometrium 2.jpg
[Diffuse large B-Cell Lymphoma]
22 yrs old female underwent DC procedure with suspition of acute oophoritis and endometritis.  
HISTO: 1. Signs of chronic bleeding (siderin). 2. single multinucleated cells (megas?).3. Microscopic focus with DLBCL quality.  
IH: CD20+ Bcl6+ Ki67 up to 100% Bcl2/CD10(?)(exhausted block). Ig kappa slightly > Ig lambda.  
PCR: CLONAL on IgL kappa.  
 
PROPOSAL: Difusse large B cell lymphoma?. NOTE: Treatment underlying infection (chlamydia?), full hemato-evaluation, re-biopsy.  
SPECIAL QUEST: minimal nidus+ clonality= malignancy?  
NOTE: We have had single case of full blown DLBCL in endometrium without treatment and without progression. This case is third. The second was similar, but with IgH clonality.  
Sender: ugnius
2008-04-08 12:39
INCTR - EBMWG Hematopathology Online

Last modified: 2008-04-08 12:39:59