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Secondary skin involvement by CLL, in progression, probably EBV-associated. (5438) » CD23 deep 2.jpg
Filename: CD23 deep 2.jpg
[Secondary skin involvement by CLL, in progression, probably EBV-associated.]
80 yrs woman was biopsied and recently operated due to tumor inthe sacral skin.  
HISTO: B marginal zone lymphoma with plasmoid features.  
IH B POPULATION: CD20(++) 100%, Ki67 low 30% (++), CD23(++) 40% (large cells), CD43(+++) 100%, Bcl6(+/++) 10% (rudimentary FC?), CD10(-), CD5(+/++) 40%, IgM(+++) 100%, IgD(+++) 90%, Mum1(-)(plasmacells +), CyclinD1(-). CD21+ FDC network absent (only rudimentary nests in ocupated follicles). Multiple CD30(+) large immunoblasts 10%, CD15-. Single EBV LPM1(++)cells. Ig kappa/lambda without restriction.  
 
PROPOSAL: B marginal zone lymphoma in the skin with aberant immunophenotype CD23?  
FINAL: CLL CD23+CD5-/+ infiltration in the skin (in ulcer/lymphoid hyperplasia background)  
SPECIAL QUEST: CD30+ large immunoblasts (reactive), single EBV+ cells, CD23+ expression?  
Thank you for participating.
Sender: ugnius
2008-04-11 13:47
INCTR - EBMWG Hematopathology Online

Last modified: 2008-04-11 13:47:47