In 2004 DLBCL was diagnosed for 67 yrs old woman in lymph node (inguinal and neck lymphadenopathy, 7x3x3cm node). Appropriate therapy was applied.  
In 2007 tumor growth was noticed in thoracic subcutis (most probable lymph node with tumoral infiltration; 1,3x1,5x1,7cm).  
HISTO: on the slides.  
IH: CD20+; Bcl6/CD10(-)(rudimentary FC +); Mum1+; IgM+; IgD-; Ig kappa/lambda+ (without restriction); CD43/CD3(-); CyclinD1(-); Bcl2+. Ki67 ~50% in tumor (~30% in overall population). CD21/CD23+ FDC network desorgnized and focally proliferating.  
PRIMARY BIOPSY (PHOTOS "PRIMARY"): THE SAME PICTURE OF MZL. Missdiagnosed most probably due to large caliber of cells in diffuse areas.  
 
WORKING DIAGNOSIS: B cell lymphoma with FDC proliferation/follicle collonisation/formation and T cell enreachement (MzL?), transformed?  
QUEST: 1. CD10 and Bcl6 lost esp in diffuse zones, remains in destructed follicles. 2. Focal neovascularized AILT like picture. 3. DLBCL quality in diffuse zones.  
 
Thank you for beeing 2gether.