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BINNARY GASTRIC DLBCL (1033228) » CD20 homogenous in BOTH.jpg
Filename: CD20 homogenous in BOTH.jpg
[BINNARY GASTRIC DLBCL]
54 yrs lady with biopsied "MALToma". Case resent to hemato for reevaluation.  
CLINICAL HISTORY: 2013 radical resection of cervical squamous carcinoma with lymphonodectomy.  
Gastric PALPABLE pyloric circular tumor with sonoscopically detected spread into anterior abdominal wall with hepatic hilar lymphadenopathy.  
PB: isolated anemia. No generalized lymphadenopathy present.  
HISTO: bicomponent DLBCL in gastric mucosa: component A more interglandular DIFFUSE, component B more solid and NODULAR.  
IH: complettelly divergent:  
SUMMARY: (nonGCB/ABC): EBER(-); CD20+; CD30+; Mum1/Bcl6/lmo2/GCET1/FoxP1+; CMYC+; CD5/Bcl2/CD10/CD138/CyclinD1(-); Ki67 prolif. index 70%.  
A: Mum1+; CD10(-); CD30+; Bcl6/LMO2(+/-); GCET1(-); FoxP1+;  
B: Mum1(-); CD10(-); CD30(-); Bcl6/LMO2+; GCET1+; FoxP1+;  
 
DIAGNOSIS: DLBCL, but probably biclonal?  
 
SPECIAL QUEST: Summarising DLBCL, ABC (by IH). But component A- pure ABC, B- more close to GCB.  
 
ThankYouALot.
Sender: ugnius
2018-12-01 13:18
INCTR - EBMWG Hematopathology Online

Last modified: 2018-12-01 13:18:19