66yrs old Lady with Acute Myelo Leukaemia diagnosis 1 yer before. First course of standard chemo was realised.  
FISH t;21). Progression and neuroleukaemia in suspitio.  
ASPIRATE: 49% blasts; MPO+ only 5%.  
FLOW: ~35% blasts in BM: CD34+, CD33+,CD7+ dim, CD61+ dim, CD41+ dim, CD42-, CD13-, HLA-DR-, CD117-, cMPO-, CD14-, CD64-, CD56-, CD11c-, CD7-, CD2-, CD1a-, CD4-, CD8-, CD22-, CD19-, CD20-, CD10-, CD15-, cTdT-, cCD3-, cCD79a-. AML M7 POSSIBLE.  
BLOOD: WBC (*10e9/l) 30,8; HgB (g/l) 99; Plt (x10e9/l) 422.  
HISTO: in the virtual slides and snapshots. Pleomorphic blasts with multilobated nuclei vWF+ closed to more conventional blasts.  
IH: CD117+/-; CD34+; vWF+; Pax-5+ (possibly asociated with t(8;21); CD7+; TdT/CD68/CD4/CD56/MPO(-); CD2/CD5(-).  
 
PROPOSAL: Acute myeloleukaemia, 85% BM. Fe deposition.  
QUESTION: 1. The possibility of subclassification (M7 like: vWF+; CD61- partially? or additional genetic changes in suspition?). 2. Usually t(8;21) asoc with good prognosis and Pax5+ (it does not take place there).