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DLBCL evolving from low grade lymphoma,probably marginal zone lymphoma (aberrant Bcl6 expression), M /73 (10622) » LN2 blastic.jpg
Filename: LN2 blastic.jpg
[DLBCL evolving from low grade lymphoma,probably marginal zone lymphoma (aberrant Bcl6 expression), M /73]
CONVENTIONAL PHOTOS PENDING.  
history: 73 yrs old male with cervical lymphadenopathy. 3 biopsies were taken: LN1 from the neck (2009 Feb), threpine biopsy (2009 May, staging) and LN2 from supraclavicular LN.  
HISTO: 2 cell populations: 1) DLBCL (immunoblastic) with Ki67 ~40%; 2) lymphoplasmacytic/"paraimunoblastic" low grade with Ki67 ~5%. FDC networks are absent (CD21/CD23). The "maconudolarity" without FDC is present in some extent.  
IH: Bcl6+; Mum1+; Ig kappa+; IgM+; CD10(-); Bcl2+; CD43+; CD5/CD23/CD30(-); CD79a+ > CD20+ (CLL or "marginal/plasmoid" like pattern).  
BM: Unsatisfactory for full IH panel, CD20+ lymphoid infiltration about 10% NOS (not included in photos).  
VIRTUAL SLIDES: APPERIO.  
JPG: snapshots from virtual slides.  
DIAGNOSIS: Diffuse large B cell lymphoma, probably evolving from B low grade lymphoma (MzL with aberrant Bcl6+ vs FL)?  
 
SPECIAL QUEST: The interpretation of B low grade component.  
 
Thank you for beeing 2gether for a long long time.
Sender: ugnius
2009-10-20 10:47
INCTR - EBMWG Hematopathology Online

Last modified: 2009-10-20 12:09:54