Female 70 years old, with tumours in both ovaries (hysterectomia with bilateral adnexectomia was made).
MACRO: Greyish, brown with rough surface tumour occupying whole ovary, forming 7cm - in one and ~14 cm mass in another ovary.
MICRO: various size confluent nodules and diffuse areas of large polygonal, clear cell outlines cells with abundant eosinophilic cytoplasm and round nucleus and alternating zones of smaller spindle-shaped cells. Zonal higher cells polymorphism, necrosis and haemorrhages. There are small groups of smaller eosinofilic monomorphic cells around some nodules. Few high-power fields with 1-2 mitoses.
IMUNO: Tumour: WT1 (+) 100%, Calretinin (+)~40%, Inhibin (+)~10%, Ki67 (+) 2-3%, ER (++/+++), Hepa (+) single cells. Inhibin ir Calretinin (+)smaller eosinophilic cells.