77 yrs old woman with lymphadenopathy in the neck and axillae and visceral. CLIN: LDH elevated (469), splenomegaly. Blood counts: WBC 5.89 (N), Eo 0.65 (N 0.45), PLT 126 (N 180-320).

Neck LN biopsy was performed.

HISTO: on the slides: binary cell population: histioid with wrincled nuclei and more peripheral "blastoid".

IH: binary cell population: 1) LC: LCA+; CD4+; CD45RO+; S100+; CD68(-); CD1a+; CD7-/+; CD117+/-; TdT(-); CD34(-); Ki67+ 40%; 2) T LBL: CD7+;TdT+.; CD34+; CD7+; Bcl2+; CD4+; CD45RO(-); CD43+; CD2/CD5/CD3/CD8(-). Ki67+ 70%;

PROPOSAL: T-LYMPHOBLASTIC LYMPHOMA/LEUKAEMIA  (BINARY POPULATION ? LANGERHANS CELL SARCOMA ASSOCIATED WITH ?)

Thank you beeing so close.