70yrs old female 2007 04 26 underwent 2,5cm lymph node biopsy with clin diagnosis "lymphoma".  
HISTORY: In the beginning of 2007: fever and postive blood culture (NOS). AB treatment + steroids. Diagnosis: sepsis. In the moment of LN biopsy: neck lymphadenopathy, blood test normal, ESR and CRB normalized. Ig evaluation was not performed (I've request it now).  
Diagnosis B marginal zone lymphoma was made. Threpine biopsy results: "reactive changes".  
2007 06 06 core biopsy from inquinal lymph node was repeated due to clinical suspition of "transformation to DLBCL".  
HISTO 1 (primary node): 1. B marginaloid monotonous proliferation of "plasmacytoid" B cells with Ig kappa restriction. 2. Some eras seems to be CD3-CD20-: photos No.14-15 (staining?)3. There some CD68+ multinucleated cells with hemophagocytosis. Some dim CD68+ reaction in "marginaloid" population. 4. There are some interstitial CD30+ CD15-CD3-CD20-/+(single +) giant cell accumulations with HL features. 5. The cytology of small lymphos, "marginaloid" cells and giants are demonstrated well in photo No.42.6. There are slingle CD138+ cells in sinus area.  
HISTO 2 (core biopsy LOW QUALITY): 1. T CD3+ population with a little angulated nuclei with some admixture CD20+ cell. 2. High Ki67 activity. 3. The same giant cells CD30+.  
HISTO 3 (core biopsy): 1. Diffuse clear CD3+/Bcl2+ T cell population with some PROMINENT and PALE areas of CD21+ FDC proliferation, "neovascularity", some pleomorphic T (sic!) cells and some faintly CD30+/- andCD15- cells. 2. Residual CD20+ small lymphoid nodules with Mum1+ scattered cells.  
 
MOLECS: 1. PRIMARY node: B monoclonal Ig kapa, polyclonal IgH and TCR beta monoclonal. 3. Last core biopsy: T monoclonal. B was not done (B population is scant).  
 
DIAGNOSIS: 1. LYMPH NODE: B marginal zone lymphoma with prominent plasmacytoid/activated zomponent and HL like giant cells (transformation?) 2. CORE: Atypical T lymphoid proliferation with HL like cells (transformation?). 3. Atypical T lymphoid proliferation (transformation to AILT)???  
 
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