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DD.: atypical reactive lymphadenitis / DLBCL (3331) » Slika 4.jpg
Filename: Slika 4.jpg
[DD.: atypical reactive lymphadenitis / DLBCL]
We present here an interesting case of lymph node along cystic duct, routinely taken for examination during the section of the gall bladder in a 65-year-old Bosnian male.  
On gross examination, lymph node did not exibit any changes.  
Microscopically, in paracortical areas of the lymph node proliferation of large, atypical lymphocytes with prominent nucleoli was noticed (immunoblast like cells). These lymphocytes had abundant cytoplasm, which was mainly eosinophilic. The same picture with atypical lymphocytes were seen in surrounding fat tissue (see Fig. 6).  
Additional immunohistochemical analysis revealed that lymphocyted exibited positivity for CD20 and bcl-2, focally for CD10, CD38, lambda and IgM whereas bcl-6, CD3, CD5, CD30, CD43, cyclin D1 and cytokeratin were negative.  
From patient's history we found out that he suffered of unresectable pancreatic carcinoma.  
Diagnosis: Malignant lymphoma or paracortical hyperplasia?  
Please, give your opinion!
Sender: semir
2007-06-28 15:37
INCTR - EBMWG Hematopathology Online

Last modified: 2007-06-28 15:37:58