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Urothelial carcinoma (363160) » HE 10x 1.jpg
Filename: HE 10x 1.jpg
[Urothelial carcinoma]
74 years old man.  
Transurethral resection of the bladder tumour was made.  
 
Microscopic view:  
Fragments of fibromuscular stroma with transitional epithelium and infiltrative tumour, composed of nests and solid areas of medium sized cells with eccentricaly located polymorphous nuclei and light, clear margin cytoplasm with "friable" inclusions and focaly with PAS+ intracytoplasmic globules. Wide zones of necrosis.  
There is conventional high grade transitional cell carcinoma next to the latter mentioned.  
 
Immunohistology: PANCK+, CKHMW+, CK7/CK20+, pCEA+, CD138+ focal 30%, CK5(-), TTF1/CDX2(-), PSA(-), Vimentin(-).  
EBER CISH(-).  
 
My thoughts is about plasmacytoid transitional cell carcinoma.  
Questions: what about intracytoplasmic inclusions and PAS+ globules?  
Immunohistochemistry - CD138 is it specific and is it enough 30% of all tumour volume?  
 
I would appreciate any other opinion.
Sender: simvai
2011-05-03 11:15
INCTR - Lithuanian Pathology online
HE 10x conventional carcinoma component

HE 10x conventional carcinoma component
Last modified: 2011-05-03 11:16:12