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Reactive, "inflammatory pseudotumor like" lesion (3629) » EBV10x.jpg
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[Reactive, "inflammatory pseudotumor like" lesion]
We present here a new case of the pulmonary lesion that developed in a 40-year-old Bosnian female previously diagnozed with Hodgkin disease. The diagnosis of HD was established in January 2006 based upon mediastinal and hilar lymphadenopathy. Subsequent chemotherapy for HD was induced.  
Now, on routine X ray, solitary lung lesion was detected. The lesion measured 2x1.7 cm. No signs of mediastinal lymphadenopathy.  
The lesion was surgically removed.  
Due to comparison we will set up the slides of both lesions (the first one diagnozed in 2006 and new one from the lung).  
The first lesion diagnozed as HD was composed of mixed cell types including lymphocytes, plasma cells, eosinophils and single, large mononuclear cells (lacunar cells). Single, Reed-Sternberg like cells were also seen (CD30+). Both morphological and immunohistochemical criteria fit the diagnosis of HD.  
Now, the patient developed multiple granuloma-like lesions in her lowe right lung lobe. Granulomas contained a lot of histocytes (CD68 diffusely positive), eosinophils, lymphocytes (pan-T, CD3+) and large, mononuclear, lacunar-like cells (negative for CD30 & CD15).  
Other IHQ: HMB45(-), SMA(-), CD20(-), S100(-), AE1/AE3 (stained only respiratory epithelium).  
Clinical diagnosis: No  
Histopathological diagnosis: Drug-induced pneumonitis, HD or?  
Please, give your opinion.
Sender: nurija
(case: semir)
2007-09-12 10:44
INCTR - EBMWG Hematopathology Online

Last modified: 2007-09-12 10:44:38