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gray zone lymphoma? (365156) » CD30 11.jpg
Filename: CD30 11.jpg
[gray zone lymphoma?]
17 yo girl with history of progressing cervical lymphadenopathy since late March. No B-symptoms until the last week, when she noticed fever and minimal weight loss. Imaging - bulky cervical and mediastinal process, no other sites involved. Mild neutrophil leukocytosis (WBC 13.000, nf 79%), PLT 650.000, mild iron deficiency, LDH and CRP only slightly elevated.  
Supraclavicular lymph node biopsy showed sheets of large to giant very pleomorphic cells, stellated necroses, only occasional collagen bands.  
Phenotype: LCA negative/weak, CD30+, CD15+, CD3-, ALK1-, CD20+, CD79a-, PAX5 negative/weak, MUM1+, CD138 partly+, EMA weakly+ (sorry, no pic!), bcl2+, CD10-, bcl6-, EBV LMP1- (I have no other options), CK AE1/3-, Ki67 about 30%.  
No infiltration on marrow cytology and trephine.  
The question: does it fit the gray zone (between DLBCL and cHL) or just cHL?  
A by-thought: bcl2 is bad for HL, could it be the same here?  
 
Many thanks for assistance!  
 
P.S. Meanwhile, the girl turned 18 and was transferred to the adult hospital with all biopsy material.
Sender: SergeyN
2011-05-13 19:38
INCTR - EBMWG Hematopathology Online

Last modified: 2011-05-13 19:38:50