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PTCL and AILT border (follicular) (374024)

PTCL and AILT border (follicular)
Subtitle: B11-19982

Type:
NOE

Sender:
ugnius

2011-07-01 17:10
INCTR - EBMWG Hematopathology Online

69 yrs old male underwent lateral neck node biopsy. Threpine with nodular/focal involvement of lymphoma (below)(not included in photos).

HISTO: on the slides: nodular infiltration of small/medium T cells with CD3+ CD10+ phenotype in the outer part of irregular follicles and in between. Small interfollicular irregular area of infiltration is present. Sinuses obliterated fully.

IH: tumoral T population: CD5(-), CD3/CD2/CD7(+++)100%; CD4(+/+++)70%; CD8(+++)30%; Ki67(++/+++) 50%; EBV-LMP1 /EBERsingle cells +; CD10 (+/+++)50%; Granzym B (-)(probably reactive CD8+ pool +); CD20+ small/medium lymphos displaced by CD3+ nodules. CD23/CD21 nodular FDC proliferations.

PROPOSAL: T angioimunoblastic lymphoma (AILT) (with "follicular" pattern in part (70%) vs PTCL, NOS (follicular in part).

Thankyouforyourinput.

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ugnius 2011-07-01 17:33	The case is ready.
tzankov 2011-07-01 18:18	In my opinion the case fulfills diagnostic criteria of AITL, pattern I and II and not of "pure" follicular T-cell lymphoma (upon all, both AITL and F-PTCL share a lot of genetical similarities). EBER is working in your lab, congratulations!
ugnius 2011-07-01 18:22	Thanx, dr.Alex, for late Friday support. The case refered as AILT. Really I have had no "pure" follicular PTCL yet...

Last modified: 2011-07-01 17:33:23