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Axillary lymphadenopathy in a 42-year-old female (3946) » EMA.jpg
Filename: EMA.jpg
[Axillary lymphadenopathy in a 42-year-old female]
We present here a new case of the enlarged left axillary lymph node in a 42-year-old Bosnian female. She has got a pain in her left arm that has persisted for several weeks.  
On clinical examination, enlarged axillary lymph nodes were noticed. Two lymph nodes were surgically removed for diagnostic purposes.  
No other signs of the disease. Laboratory findings unremarkable.  
Gross examination revealed the presence two lymph nodes of which the first one measured 4x2.5 cm wheares the second one measured 2x1.5 cm.  
Microscopically, prominent thickening of the capsule of the lymph node was seen as well as a reactive, follicular hyperplasia. However, in several focuses within the lymphatic vessels, emboli of single, large cells with moderately abundant cytoplasm, large nuclei with prominent nucleoli were seen. These cells showed prominent pleomorphism and sporadic mitotic figures.  
Immunohistochemistry: Cytokeratin AE1-AE3 (negative), CK8 (negative), LCA (negative in the cells within the vessels), CD30 (positive), EMA (positive), S100 (negative), CD34 (positive, stains clearly the walls of the vessels).  
Clinical diagnosis: No  
Histopathological diagnosis: Reactive follicular hyperplasia of the lymph node with emboli of the tumor cells  
The origins of tumor cells: Anaplastic large cell lymphoma (ALCL), epitheloid sarcoma, metastatic carcinoma or?  
Please, give your opinions!
Sender: semir
2007-10-22 10:47
INCTR - EBMWG Hematopathology Online

Last modified: 2007-10-22 10:47:47