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Hyperplasia of erthropoiesis and megakaryopoiesis, due to increased demand in the periphery megaloblastic erythropoiesis (4033) » Giemsa 1.jpg
Filename: Giemsa 1.jpg
[Hyperplasia of erthropoiesis and megakaryopoiesis, due to increased demand in the periphery megaloblastic erythropoiesis]
One more new case from us: It is about bone marrow findings in a 46-year-old Bosnian female that presented with signs of anemia and thrombocytopenia for several years.  
Bone marrow biopsy has been performed and the findings are presented here.  
Microscopically, hypercellular bone marrow was seen. Proliferation of platelates in all phases of development was prominent (sporadically and in aggregates). These cells were positive for CD117 (c-Kit) and von-Willebrand factor (VIII factor). Dyserithropoesis with megoblastic cells as well as dysplastic myelo (mono- and binuclear) cells were also present (MPO and LCA positive). Bone marrow contained also a reactive population of plasma cells (CD38 positive).  
Clinical diagnosis: Pancytopenia  
Histopathological diagnosis: Myelodysplastic syndrome (MDS)?  
Therapy: Not so far (the open question is how to treat this patient in order to prevent a progression to acute leukemia)?  
Please, give your opinion!
Sender: semir
2007-11-07 11:07
INCTR - EBMWG Hematopathology Online

Last modified: 2007-11-07 11:07:39