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Brain tumor (414388)
Brain tumornew
Subtitle: Meningioma
Type:
Biopsy
Sender:
jakob
2012-03-31 16:24
INCTR - Pathology Anglophone Africa
12.64
 

 
M   16
 
Hard  and   cystic  mass     fronto-temporo-parietal  area.
 
Received:  4  tiny    fragments,   1  cm  in  aggregate.
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jakob
2012-03-31 16:27
Despite the age, - could this be a rhabdoid meningioma ?
Seth
2012-03-31 17:55
I presume that this tumour was partly superficial/extra-axial. I think meningioma is a possibility but I can't see any definite meningothelial differentiation. There are a few cells with eccentrically placed nuclei and homogeneous eosinophilic cytoplasm but I'd have expected these to be more numerous in a rhabdoid meningioma, and extensive fibrosis would be very unusual for that diagnosis. I am struck by the difference between the appearance of the very elongated, spindle-shaped cells in DSCN6338 and that of the rounded, pleomorphic cells in DSCN6333 and DSCN6337. Are the non-spindled, pleomorphic cells within reticulin-free islands? If so, I'd think of a desmoplastic infantile astrocytoma or desmoplastic infantile ganglioglioma; these usually occur in much younger patients but have been reported in adolescents. Immunohistochemistry for GFAP and a neuronal antigen (e.g. neurofilament protein or synaptophysin) would be helpful, if available.
KSivaraman
2012-04-03 09:49
I was thinking in terms of a glioma - ganglioglioma, pleomorphic xanthoastrocytoma.
Last modified: 2012-03-31 16:24:31