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ALCL ALK1-, focally CD15+ tumor cells (4123) » Granzym B sinus.jpg
Filename: Granzym B sinus.jpg
[ALCL ALK1-, focally CD15+ tumor cells]
Painfull "Occipital neurofibroma" was resected for 59 yrs female with 2yrs (sic!!!) history.  
HISTO: Sinus and wedge shaped infiltrate of atypical T cells in lymph node.  
IH: CD3+ CD4+ GranzymB+ CD30+ ALK1/EMA-. Ki67 ~60-70%. The single PanCK+ cells. The block is exhausted due to low quality: LEFT material: CD23+ netwrok in FC; CD10-; CD43 and some stains from another block are pending.  
HISTORY: After bee bite (2 yrs before) the patient palpates occipital LN, soon after- oethr LN slowly grow up. Any skin damage before and nowadays is present. BLOOD and LDH: normal values; HEPATOSPLENOMEGALY: NOT; ESR 42; Cervical LN on CT scan: up to 0,6-0,8cm. Visceral nodes: normal. GI endoscopy: normal.  
BM biopsy: in the progress.  
PROPOSAL: Peripheral T lymphoma.  
QUESTION: The possibility of transformed mycosis spread to lymph node.  
WORKING/FINAL: Anaplastic large cell (T) lymphoma, ALK1(-) in lymph node.  
 
Thank you for participation.
Sender: ugnius
2007-11-27 20:58
INCTR - EBMWG Hematopathology Online

Last modified: 2007-11-27 20:58:44