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CD8+ Lymphoproliferation (4478) » CD68 b.jpg
Filename: CD68 b.jpg
[CD8+ Lymphoproliferation]
22 yrs old male with polyserositis, fever, hemolytic anemia and liver failure. Original diagnosis (LN biopsy): "Peripheral T lymphoma".  
HISTORY (EVENTS): 1. Antibiotic treatment with suspition of odontogenic sepsis (tooth extraction after fever, myalgia and sore throat presentation). 2. Pleuritis, pericarditis, hepatomegaly. Prednisone therapy. 3. Acute hepatorenal insufficiency. Dialysis. 4. Candida+ in blood culture. Antibiotic treatment.  
5. After improvement of symptoms the patient redirected to HEMATOLOGY dept. (biopsy results).  
HISTO (CONSULTATION CASE): The diffuse CD3+ CD2/CD5/CD7+ CD8+>CD4+ GranzymB/Perforin+ medium-large sized pleomorphic T cell infiltration with prominent diffuse apoptosis, high proliferation rate and focal CD68+/MPO+ histio- reaction with crescentic histyocytes. Scattered CD30+, single CD56+ cells. TDT/CD34/ALK1(-). Rudimentary B zones CD20+. NECROSIS IS ABSENT.  
 
WORKING DIAGNOSIS: REACTIVE T CD8+ PROLIFERATION (KIKUCHI LYMPHADENITIS (CELLULAR PHASE)) VS ...  
 
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Sender: ugnius
2007-12-21 10:31
INCTR - EBMWG Hematopathology Online

Last modified: 2007-12-21 10:31:20