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ONE MORE LOOK TO THE OLD CASE (4970) » NEW GranzymB nodular.jpg
Filename: NEW GranzymB nodular.jpg
[ONE MORE LOOK TO THE OLD CASE]
This case is linked to HISTOPATHOLOGY group. Please take a look once more- some new stains and thoughts about this "Eo reach T cell proliferation with high Ki67 activity and high density of vessels".  
EXPANDED IH: The infiltrate: CD3+ CD2+ CD5+ CD7(sic!)(-), TIA1+, GranzymB/Perforin-/+, CD30-/+, Ki67 prolif. activity up to 40%; CD8/CD4 ~2/1; CD23+ FDC network is absent. EBV LMP1 is negative.  
IN PROGRESS: CD21, CD68, S100, CD1a, CD117.  
HISTO FEATURES: Coagulative slit like necrosis; Slight nodularity and angiocentrism with slightly pleomorphic spindle cell proliferation; mitotic activity and nuclear irregularities in T population even in medium cellular zones; PROMINENT eosinophilic infiltration.  
 
WORKING/QUESTION: ATYPICAL T PROLIFERATION: peripheral T cell lymphoma, cytotoxic immunophenotype?  
Thank you for collaboration.
Sender: ugnius
2008-03-09 16:13
INCTR - EBMWG Hematopathology Online

Last modified: 2008-03-09 16:13:19