83 yrs old male with previous core biopsy (inguinal node): "Aggressive B LPD with IH: PAX5/MUM1/CD30+, BCL6+(40%), CD21+, LCA+/-, OCT2(+/-), BOB1(+/-), KI67: 90%, CD20/CD79A(-), CD15(-), CD138/KAPPA/LAMBDA(-), ALK1(-), CD22(-), CD3/CD2/CD5/CD7/GRANZYMB(-), EBER_CISH(-).  
DLBCL with aberrant IH probable".  
 
WHOLE node biopsy was taken.  
HISTO: Nodular architecture with some septation. Nodules with peripheral rim of T lymphos, second inner CD68+ Ma rim and central nodular part formed by large mononuclear cells with necrosis and admixture of eo's.  
IH: the same. More clearly visible, that tumor cells Pax5+; CD20/CD79a/Oct2(-); EBER/LMP1(-); BOB1+ only singles; LCA(-)(except outer rim of macrophages, creating BINARY architecture of the nodules.  
MOLECS: IGH ir IGK polyclonal. TCRB V-D-J1/2 possibly clonal in the polyclonal background. TCRG polyclonal.  
 
INTERESTING FEATURE: aberrant CD21 positivity (described before:  
Kim SH1, Choe JY, Jeon Y et al. Frequent expression of follicular dendritic cell markers in Hodgkin lymphoma and anaplastic large cell lymphoma. J Clin Pathol. 2013 Jul;66(7):589-96. doi: 10.1136/jclinpath-2012-201425).  
 
PROPOSAL: CHL NS grade 2 (sintycial)?  
 
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