85 yrs male with 3x2,6x1,6 cm node biopsy with suspition of NHL.  
HISTO: NODULAR (sic!) architecture with anaplastic/large cell content and B phenotype.  
IH: LCA+ 100%, CD20+ 100%, PAX5+ 100%, BOB1+ 100%, Oct2+ 100%, CD30+, CD15-, Mum1+ 40%, Bcl6+ 60%, Bcl2+, CD21+ 30% (and FDC), CD10-, Ki67+ 90%, CD23- (rest of FDC+).  
MOLECS: ND.  
 
PROPOSAL: DLBCL, anplastic variant (nodular subtype).  
DX: FL G3.  
Paraphrase: previous CHL-DLBCL "grey" case: https://www.ipath-network.com/inctr/object/view/577077  
 

tzankov 2014-07-07 09:19	I fully agree with your diagnosis of an anaplastic variant of DLBCL, CD30+ (CD21+).
ugnius 2014-07-07 09:41	Thanx a lot. Some similarity to previous case.