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MYCOSIS/SEZARY vs LCH (5865) » SKIN CD3 derma 1.jpg
Filename: SKIN CD3 derma 1.jpg
[MYCOSIS/SEZARY vs LCH]
79 yrs old woman with 0,5year duration of symptoms: itching, dark coloured skin (from birth after patient's words) with papular eruption and excoriations (buttocks, hands, abdomen, inguinal skin). Peripheral (neck, axillary up to 3cm) and visceral(1,5cm paraaortic) lymphadenopathy. Eosinophilia in BM aspirate. LDH 1121 U/L. Any lymphocytosis in the blood.  
HISTO:  
1. NODE BIOPSY (inguinal): Dermatopathic/LCH like picture with binary S100/CD1a (dark and light) population and minimal CD3 convoluted cell component. FE deposition is absent.  
2. SKIN BIOPSY (inguinal): Linear CD3+ CD4+ infiltrate with minimal epidermothropism and convolutions.  
3. BM BIOPSY: Single CD3+ convoluted cells and CD117+ mastocyte reaction (single spindle cells) in slight fibrotic background.  
 
PROPOSAL: 1. NODE: LCH vs MYCOSIS FUNGOIDES/SEZARY S. spread in lymph node with lch/dermatopathic lymphadenopathy like reaction.  
2. SKIN: Minimal mycosis fungoides 3. BM: REACTIVE CHANGES vs minimal mycosis fungoides ???  
DIFFERENTIAL: Thank you for continous support/education.  
Sender: ugnius
2008-06-23 13:00
INCTR - EBMWG Hematopathology Online

Last modified: 2008-06-23 13:00:38