< | up | >
Nasopharyngeal mass (618373)
Nasopharyngeal massnew
Type:
Sender:
wael_alabsi
2014-12-30 07:35
INCTR - EBMWG Hematopathology Online
37 years old male, present with nasopharyngeal mass  
 
Is it Nodular Lymphocyte predominal Hodgkin's lymphoma??  
or DLBCL on top of NLPHL (Diffuse CD20 positivity)??  
 
Thanks for your opinions.
Annotations » Add comment (Login)
hoellers
2014-12-30 08:42
Dear Dr. Al Absi,  
 
thank you very much for sending this intersting case. There are for sure big CD20 positive B-cells showing a rosetting with small T-cells. The morphology of these cells is neither convincing for Hodgkin cells nor for Popcorn cells to me. The first step I would do in this case is to exclude EBV infection. Do you know how big the mass is. Are there other clincal signs like splenomegaly or hepatomegaly or lymphadenopathy. Fever? Was the Patient serologically tested for EBV? From a morphological point of view: Are all big cells CD20 positive or are there also big CD3 positive cells intermingled? Do you see signs of destruction of normal tissue or is it just an enlargement of the tonsilla pharyngea?
ugnius
2014-12-30 20:31
1. Special thanks for cytology of giant cells, being LCA-, CD30+, CD15+ So fitting into CHL like phenotype. I do not accent specially CD20+.  
2. Small lymphos and even plasma cells not so good on HE. But still present, as in MC variant of CHL.  
3. If we are true, and 37 yrs old has RARE tonsilar, extranodal, so exotic enough CHL MC - we must check EBV and immunocompetence status: HIV? Transplant? Rheumatic diseases under treatment?
tzankov
2015-01-05 16:33
the case is suspicious of classical Hodgkin lymphoma, yet the presentation as a nasopharyngeal mass is unusual and CD15 is not convincing; therefore I would sign it out as consistent with. the radiological and clinical context must be considered. EBER or LMP1 should be stained. clinicians should look up for immunosuppression.
Last modified: 2014-12-30 07:40:23