Filename: Blood.doc case: CLL and malignant vascular tumor. Clusters of blasts TdT+,CD3+ of uncertain significance.
Female, 60yrs.
History: chronic lymphocytic leukemia from 2001 (only cytology, review impossible).
Tumor of the femur nowadays, biopsy from femur.
Micro: fascicles and whorls of spindle cells, abundant, sometimes pigmented cytoplasm, slight nuclear polymorphism, mitotic figures and clusters of small T lymphocytes, with scarce cytoplasm, irregular angulated nuclei.
IH spindle cells: CyclinD1+ (nuclear), Ki67+ 20%, Bcl2+ (weak).
PanCk/CD21/CD23/EMA/AsmAct/Des/S100/CD117/CD34/ER (-).
IH lymphoid cells: CD3+, Tdt+, Cd5+, Ki67+ 80%, Cd1a+, CD20-, CD23-.
Working diagnosis: dendritic cell sarcoma AND T lymphoblastic lymphoma.
Thanking you in anticipation.
