69 yrs male with retroauricular lymphadenopathy.  
SONO: Hepatomegaly. Blood values: normal, except slight eleveation of CRB, ESR and eosinophilia (FILE IS ATTACHED).  
Lymph node biopsy was taken.  
HISTO: "Marginal" or interfollicular lymphoproliferation with "pseudo-low grade" cytology: oval- irregular pleomorphic nuclei with some "blastic" appearance" and high proliferative activity. Vascularisation CD34+ is minimal. NASDE(-) clear minimal cytoplasm.  
IH: CD3/CD2(++/+++) 100%, CD4(++/+++) 100%, CD5(+) 60% (weak), CD7/CD8(-), CD79a(-), Bcl6(++/+++) 100%, CyclinD1/CD23(-), CD20(+/++) 30% , TdT(-), CD34(-)(minimal vascular network), CD99(+/+++) 40%, CD117(-)(mastocytes +), EBV LMP1(-), CD1a(-)(focal Langerhans cell hyperplasia), CD15/MPO/CD30/ALK1(-), CD21/CD23(-). Residual CD21/CD23+ FDC networks in follicles. Ki67 prolif. activity HIGH ~70%.  
 
Cytotoxic molecules and T/B clonality pending.  
 
WORKING: High grade lymphoma with T phenotype (Peripheral T lymphoma NOS: CD3/CD4/CD2+; CD5+/-; CD7-) and aberant B (CD20; Pax5) and stem cell markers (CD99). DIFFERENTIAL: "blastic" (myeloid) leukaemia/lymphoma.  
 
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