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Cervical polyp (1589) » Ig lambda ADD.jpg
Filename: Ig lambda ADD.jpg
[Cervical polyp]
The D&C procedure (curreting of endometrium) and the removal of endocervical polyp were performed for 54yrs old woman. CLIN DGN.: Myomatosis uteri. Cervical polyp. Premenopausal bleeding. The last menses 01 20. HISTO of polyp is presented on photos below.  
IH: CD20(+) 95%, Bcl 2(-), CD3(-)(except small T lympho's), Bcl 6(+) 80%, Mum1(-)(single cells and plasmo's +), CD10(+) 30%, Ki67 (average) ~70%(clear zones- 20% and "blastic" zones-90%), CD30(+) 5% (esp. perivascularly and in the surface), CD138/CD23/EMA(-)(except plasmo's), ALK1(-).  
PROPOSED DIAGNOSIS/QUESTION: B lymphoproliferation: "LYMPHOMA LIKE LESSION" (Chlamydia, etc???) >>> DLBCL.  
COMMENT: CD20+ Bcl 6+ Bcl 2-Mum1- CENTROBLASTIC population with marginal like areas visually seems to be DLBCL on HE slides, but in this localisation the reactive lessions are more common. Is more activated immunophenotype of DLBCL more likely if it would place there?  
Thank you for comments.
Sender: ugnius
2006-03-15 15:35
INCTR - EBMWG Hematopathology Online

Last modified: 2006-03-15 15:35:48