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T lymphoproliferation vs Langerhans' cell histiocytosis (1362) » S100 1.jpg
Filename: S100 1.jpg
[T lymphoproliferation vs Langerhans' cell histiocytosis]
27 yrs old woman presents with multiple confluent painless nodules in skin (breast, back, trunck, buttocks). Excisional biopsy was performed (consultation case).  
HISTO: Irregular confluent nodular perivascular and periadnexal dermal infiltrate consist of small- medium lymphocytes with irregular, wrincled, cleaved nuclei (T) and admixture of histyocytes and eosinophils. The epidermothropism, adnexothropism are absent (single CD3+ cells in epidermis). Mitoses and atypical forms are present. Exulceration is present. The infiltrate is irregular wedge shaped with basis in upper part.  
IMMUNOHISTO (in progress): CD3+ infiltrate with mixture CD4+, CD8+ cells (ratio CD4/CD8 about 3-4/1), CD68+ macrophages. There are some CD56+ cells or CD30+ interstitial large cells. The multinucleated HL like cells are absent.  
PROPOSED DIAGNOSIS 1: Cutaneous T pseudolymphoma (drugs? insect bites?) >>> cutaneous T lymphoma?.  
PROPOSED DIAGNOSIS AFTER IH 2: Langerhans' cell histiocytosis?  
Thank you for comments in advance.  
FINAL DRAFT DIAGNOSIS: T pseudolymphoma with reactive LCH-like lession?  
Sender: ugnius
2005-12-01 12:01
INCTR - EBMWG Hematopathology Online

Last modified: 2005-12-01 12:01:40