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B NHL in skin (1411) » CD23 follicles 1.jpg
Filename: CD23 follicles 1.jpg
[B NHL in skin]
80 yrs woman presents with tumor like nipple- megaly without ulceration. Resection was performed due to clinical diagnosis "Paget's disease".  
HISTO: The infiltrate in dermis (with clear Grenz zone) consists of diffuse small lymhocytes with residual lymphoid follicles in the deep of infiltrate. Cytology of cells: ovoid, slightly irregular nuclei and minimal clear cytoplasm. There are single plasma cells in infiltrate. There is slight syringothropism of lymphocytes.  
IMMUNO: CD20+, CD43+, Bcl2+, CD23-/+ (some cells <5% and plasmacytes focally), CD10/Bcl 6-, CyclinD1-.  
Germinal centres of follicles: CD10+, Bcl6+, Bcl2-. Some with irregular contour, maybe colonized.  
PROPOSED DGN.: Cutaneous B marginal zone lymphoma. Very strong CD43+ and focal CD23 positivity?  
Thank you in advance for comments.  
Sender: ugnius
2005-11-20 14:44
INCTR - EBMWG Hematopathology Online

Last modified: 2005-11-20 14:44:05