The SECOND subcutaneous lymph node biopsy was done for 69yrs old lady with DGN.: DLBCL, established histologically in 2005 (biopsy of the tonsil). After DLBCL diagnosis the standard treatment with multiple CHOP was performed. Due to HCV suspition liver biopsy is planned.  
HISTO: on the photos (LN- lymph node; T- PIRMARY tonsil biopsy). LYMPH NODE: The vague nodular and diffuse infiltrate consists of small- medium and single large monocytoid and plasmacytoid cells with oval nuclei. TONSIL: Exulcerated tonsil with diffuse infiltrate consisting of diffuse infiltrate of medium- large sized cells, some with vesiculated irregular nuclei and amphophylic nucleoli. A lot of apoptotic bodies are present. The plasmacytes are present.  
IH: on the photos with the same abreviations. LYMPH NODE: CD23+ disrupted FDC network with rudimentary Bcl6+ follicular center cells and Mum1+ activated cells and plasmocytes. The infiltrate: CD20+, CD43- (some larger cells maybe +), CylinD1-. Ki67+ fraction about 20% with exception of rudimentary follicular center with higher activity.  
TONSIL: CD20+ population with EMA/Mum1+ plasmacytes. Some cells Mum1+ are with irregular large nuclei, single p53+ cells. Ki67 fraction is higher than in lymph node- about 50-60%. EBV LMP1(-). Bcl2 positivity in the large cells is lower then in lymph node (low grade component). Single groups of Bcl6 probably represent the rest of follicle center cells. CD23 network is totally absent. Some CD30+ atypical cells with lobated nuclei.  
DIAGNOSIS 2 (LN): B marginal zone lymphoma.  
REVISED DIAGNOSIS 1 (tonsil): DLBCL???  
Thank you for collaboration.