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Richter, but nor CHL, nor DLBCL: NEW category by WHO? (754255) » Pax5 heterogenous.jpg
Filename: Pax5 heterogenous.jpg
[Richter, but nor CHL, nor DLBCL: NEW category by WHO?]
YOU ARE WELLCOME!  
 
67 yrs old lady with long story of B CLL/SLL (in 2013 threpine with 30% invoilvement: NOT INCLUDED here).  
Lymph node biopsy was performed (1.2cm; location ND).  
 
HISTO: Diffuse and vaguelly nodular architecture, reminescent of "accelerated" B CLL. Interstitial multiple "immunoblastoid" and giant cells with EBER+ CD30+ Pax5+ faint CD15(-) BOB1/Oct2+ attenuated B programme (CHL like).  
Context: CD23+ CD5+ small medium B CLL/SLL population.  
 
PROPOSED DIAGNOSIS: B Aggressive lymphoma/Richter's (B CLL/SLL) transformation in the context of B CLL/SLL (accelerated/progression phase).  
QUESTION: a DEFINITE name of this Richter;s: "T cell rich B cell lymphoma EBV+, CHL like"? Or maybe Accelerated B CLL/SLL with EBER+ cells and high Ki67 index?  
 
"To West (Basel)" :).
Sender: ugnius
2016-06-18 10:34
INCTR - EBMWG Hematopathology Online

Last modified: 2016-06-18 10:34:59