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Visceral atypical lymphadenopathy with storiform fibrosis/sclerosis (956294) » CD20+ panorama.jpg
Filename: CD20+ panorama.jpg
[Visceral atypical lymphadenopathy with storiform fibrosis/sclerosis]
CASE IS OPEN:  
"SURGICAL" ABDOMINAL PATIENT (NO DATA ABOUT HEMATO TO DATE):  
43 yrs old female with visceral lymphadenopathy: regional lymphonodectomy was performed, thinking about tumor in largest node.  
CLINICAL: ~3cm "tumor" from mesocolon, between v.cava inf. and duodenum (GIST vs Sa?).  
MACRO: 3x2,4x2,5 cm firm, whote/yellowish node and smaller lymph node (NOT INCLUDED THERE).  
 
HISTO: Interfollicular/internodular massive storiform sclerosis with voluminous foci. No amyloid deposits. Nodules like I follicles (with admixture CD23+ cells, dendritic networks), II follicles practically absent. The small calcificates present. Cytology: small medium lymphos with slightly irregular nuclei.  
 
IH: No definite abberancies present (CD20+ slightly heterogenous; p27+; CD23/CD21/CD35+ (focal); Bcl2+; CD5/CyclinD1/CD10/Bcl6/MNDA1(-); IgM+ > IgD+ > IgG+); Ki67 index low <5%.  
 
MOLECULAR: B and T non-clonal. MYD88 mutation absent.  
 
PROPOSAL: Atypical lymphadenopathy (IgL not- monotypic) with storiform fibrosis and some "castleman/oid" features:  
- Autoimmune diseases (Lupus? other?);  
- B marginal zone lymphoma possible vs other (B SLL/CLL? other?).  
 
 
ThankYouForBeeingTogether.
Sender: ugnius
2018-03-29 08:26
INCTR - EBMWG Hematopathology Online

Last modified: 2018-03-29 08:26:16