CASE IS OPEN:
"SURGICAL" ABDOMINAL PATIENT (NO DATA ABOUT HEMATO TO DATE):
43 yrs old female with visceral lymphadenopathy: regional lymphonodectomy was performed, thinking about tumor in largest node.
CLINICAL: ~3cm "tumor" from mesocolon, between v.cava inf. and duodenum (GIST vs Sa?).
MACRO: 3x2,4x2,5 cm firm, whote/yellowish node and smaller lymph node (NOT INCLUDED THERE).
HISTO: Interfollicular/internodular massive storiform sclerosis with voluminous foci. No amyloid deposits. Nodules like I follicles (with admixture CD23+ cells, dendritic networks), II follicles practically absent. The small calcificates present. Cytology: small medium lymphos with slightly irregular nuclei.
MOLECULAR: B and T non-clonal. MYD88 mutation absent.
PROPOSAL: Atypical lymphadenopathy (IgL not- monotypic) with storiform fibrosis and some "castleman/oid" features:
- Autoimmune diseases (Lupus? other?);
- B marginal zone lymphoma possible vs other (B SLL/CLL? other?).